Treatments, side by side
What each one is approved for, how you take it and what it costs without insurance, checked against FDA labels and each provider’s own price page.
We’re paid when you sign up with a provider through our links. We also name providers that don’t pay us, so you can see the whole market. How we make money
Weight loss
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How you take it
Weekly injection
Long-term weight reduction (adults, and children 12 and older)
Self-pay price
$349 a month self-pay at NovoCare Pharmacy ($199 for the first two fills at 0.25 mg and 0.5 mg through Dec 31, 2026; $399 for 7.2 mg).
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How you take it
Daily pill
Long-term weight reduction (adults)
Self-pay price
$149 (1.5 mg), $199 (4 mg) and $299 (9 mg and 25 mg) a month self-pay at NovoCare Pharmacy, labeled a limited-time offer.
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How you take it
Weekly injection (vial or KwikPen)
Long-term weight reduction (adults)
Self-pay price
$299 (2.5 mg), $399 (5 mg) and $449 (7.5 to 15 mg, if you refill within 45 days) a month self-pay at LillyDirect.
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How you take it
Daily pill
Long-term weight reduction (adults)
Self-pay price
$149 (0.8 mg and 2.5 mg), $199 (5.5 mg) and $299 (9 mg and up) a month self-pay at LillyDirect; some prices are reduced through Dec 31, 2026.
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How you take it
Weekly injection
Blood sugar control in adults with type 2 diabetes
Self-pay price
Listed at $199 a month on TrumpRx.gov (dose not published); list price $1,028.
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How you take it
Weekly injection
Blood sugar control in type 2 diabetes (adults and children 10 and older)
Self-pay price
Usually filled through insurance for type 2 diabetes. For weight loss, Zepbound is the same medicine with self-pay prices from $299 a month.
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How you take it
Daily injection
Long-term weight reduction (adults, and children 12 and older over 60 kg)
Self-pay price
Generic liraglutide is available; prices vary by pharmacy.
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Semaglutide
Semaglutide
How you take it
Weekly injection or daily pill
Sold as Wegovy (weight loss), Ozempic and Rybelsus (type 2 diabetes)
Self-pay price
Wegovy self-pay is $349 to $399 after two $199 starter fills for new patients.
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Tirzepatide
Tirzepatide
How you take it
Weekly injection
Sold as Zepbound (weight loss, sleep apnea) and Mounjaro (type 2 diabetes)
Self-pay price
Zepbound self-pay is $299 to $449 with on-time refills.
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How you take it
Injection (vial) or tablet
Not FDA-approved
Self-pay price
Not published at the 0 programs we track, as of Invalid Date.
Erectile dysfunction
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How you take it
Tablet
Erectile dysfunction (Viagra and its generics)
Self-pay price
Generic sildenafil costs $1.60 to $6.25 a dose at the online providers we checked, or from $16 a month for 30 doses over 90 days (Oct 18, 2026).
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How you take it
Tablet
Erectile dysfunction, as needed or once daily
Self-pay price
Daily generic tadalafil from $40 a month (one provider sells it at $2 a tablet during a sale, with no regular price published); as-needed tablets $3.33 to $25 each at regular prices at the online providers we checked, the top being a pack PeterMD had on sale at $7.25 a tablet (Oct 18, 2026).
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Vardenafil
Vardenafil hydrochloride · Generic manufacturers; brand-name Levitra and Staxyn are discontinued
FDA-approved
How you take it
Tablet
Erectile dysfunction
Self-pay price
The providers we track don’t publish a price for generic vardenafil tablets. Compounded vardenafil costs $4.34 a tablet at BlueChew and from $59.99 a month at Maximus; neither is FDA-approved (Oct 18, 2026).
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How you take it
Tablet
Erectile dysfunction
Self-pay price
None of the online providers we track publishes an avanafil price (Oct 18, 2026).
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How you take it
Tablet (25 mg, 50 mg, 100 mg)
Erectile dysfunction
Self-pay price
Brand-name Viagra costs $96 a dose at Rex MD and $139 at Hims; generic sildenafil costs $1.60 to $6.25 a dose online (Oct 18, 2026).
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How you take it
Tablet (2.5 mg, 5 mg, 10 mg, 20 mg)
Erectile dysfunction, as needed or once daily
Self-pay price
Brand-name Cialis costs from $29 a dose at Rex MD, and $958 a month for daily use at Hims; daily generic tadalafil starts at $40 a month (Oct 18, 2026).
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Compounded ED chewables
Sildenafil, tadalafil or vardenafil, one per product
Compounded; not FDA-approved
How you take it
Chewable, sublingual or dissolving tablet; some providers compound capsules
Not FDA-approved
Self-pay price
Chewables from $20 a month (BlueChew’s lowest plan) to $59 (MangoRx), or $3.53 to $4.47 a tablet at BlueChew; other compounded forms from $49.99 a month at Maximus (Oct 18, 2026).
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Premature ejaculation treatment
Sertraline or paroxetine (off-label); lidocaine or lidocaine-prilocaine sprays
Approved drug, prescribed off-label
How you take it
Tablet, capsule or topical spray
No drug is FDA-approved for premature ejaculation in the US
Self-pay price
Sertraline from $27 a month at Rex MD (Oct 18, 2026).
Hair loss
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How you take it
Daily 1 mg tablet
Male pattern hair loss (androgenetic alopecia) in men only
Self-pay price
None of the online providers we compare publishes a price for generic finasteride tablets.
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Topical minoxidil (Rogaine and generics)
Minoxidil · Rogaine and generic over-the-counter brands
FDA-approved
How you take it
2% or 5% solution, or 5% foam
Hereditary hair loss on the top of the scalp, without a prescription (men’s and women’s products)
Self-pay price
$12.67 to $15 a month at the providers that publish a monthly price (Hims foam is $19), as of October 2026; it is also sold over the counter.
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How you take it
2% prescription shampoo (1% sold over the counter)
2% shampoo: tinea (pityriasis) versicolor, a skin yeast infection
Self-pay price
From $25 a bottle at Strut Health and $33 per delivery at Keeps, as of October 2026.
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How you take it
Spray, solution, serum or gel applied to the scalp
Not FDA-approved: the FDA says there is no FDA-approved topical formulation of finasteride
Self-pay price
Compounded topical finasteride and minoxidil costs $35 to $63.20 a month at the providers that publish a monthly price, as of October 2026.
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Topical finasteride and minoxidil
Finasteride and minoxidil (often with tretinoin, ketoconazole, biotin or a steroid)
Compounded; not FDA-approved
How you take it
Spray, solution, serum, gel or drops applied to the scalp
Not FDA-approved: no topical finasteride or finasteride and minoxidil combination is FDA-approved
Self-pay price
$35 to $193 a month at the providers that publish a monthly price, as of October 2026, with any required membership included (Hone Health’s $38 plus its $155 Premium membership is the top).
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Oral finasteride and minoxidil combination
Finasteride and minoxidil (often with biotin or vitamin D3)
Compounded; not FDA-approved
How you take it
Chewable or capsule
Not FDA-approved: no oral combination of finasteride and minoxidil is FDA-approved
Self-pay price
$35 to $90 a month at the providers that publish a monthly price, as of October 2026.
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How you take it
Tablet, capsule, chewable or gummy
Not approved for hair loss. Minoxidil tablets are FDA-approved only for severe high blood pressure
Self-pay price
$18.33 to $35 a month at the providers that publish a monthly price, as of October 2026.
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How you take it
Capsule, chewable, gel or topical solution
Not approved for hair loss in the US. Dutasteride 0.5 mg capsules are FDA-approved for an enlarged prostate (BPH)
Self-pay price
$39 to $69 a month for the dutasteride products that publish a monthly price, as of October 2026.
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How you take it
Tablet, capsule or compounded topical
Not approved for hair loss. Spironolactone is FDA-approved for heart failure, high blood pressure, edema and primary hyperaldosteronism
Self-pay price
$42 to $59 a month at the providers that publish a monthly price, as of October 2026.
Testosterone
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Testosterone injection
Testosterone cypionate or testosterone enanthate · Pharmacia & Upjohn (Depo-Testosterone), Antares Pharma (Xyosted) and generic makers
FDA-approved
How you take it
Injection into muscle (cypionate and enanthate) or under the skin (Xyosted)
Primary hypogonadism (congenital or acquired) in adult males
Self-pay price
Some of the lowest prices need a membership or a 6- to 12-month plan paid upfront, and first labs can cost extra.
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Testosterone gel or cream
Testosterone · Ascend Therapeutics (AndroGel 1.62%), Upsher-Smith (Vogelxo) and generic makers
FDA-approved
How you take it
Gel or solution rubbed into the skin (FDA-approved), or a compounded cream
Primary hypogonadism (congenital or acquired) in adult males
Self-pay price
Some prices need a membership or a 6-month plan, and most programs we list prescribe a compounded cream rather than an FDA-approved gel.
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Oral testosterone
Testosterone undecanoate · Marius Pharmaceuticals (Kyzatrex), Tolmar (Jatenzo), Verity Pharmaceuticals (Tlando)
FDA-approved
How you take it
Capsule
Primary hypogonadism (congenital or acquired) in adult males
Self-pay price
That range mixes FDA-approved Kyzatrex with compounded troches, and the troche price needs a membership.
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Clomiphene (Clomid)
Clomiphene citrate · Cosette Pharmaceuticals (Clomid) and generic makers
FDA-approved; used off-label here
How you take it
Tablet
Ovulatory dysfunction in women who want to become pregnant
Self-pay price
Membership fees, where they apply, are added in; Rex MD includes Clomid in its program price without a separate figure.
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hCG
Human chorionic gonadotropin · Ferring (Novarel), Organon (Pregnyl), Fresenius Kabi (generic)
FDA-approved
How you take it
Injection into muscle
Selected cases of hypogonadotropic hypogonadism (low testosterone from a pituitary deficiency) in males
Self-pay price
None of the providers we track publishes a price for an FDA-approved hCG product, as of October 2026.
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Anastrozole (Arimidex)
Anastrozole · ANI Pharmaceuticals (Arimidex) and generic makers
FDA-approved; used off-label here
How you take it
Tablet
Adjuvant treatment of hormone receptor-positive early breast cancer in postmenopausal women
Self-pay price
Membership fees, where they apply, are added in; Henry Meds includes an unnamed aromatase inhibitor at no extra cost when prescribed.
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How you take it
Capsule or tablet, compounded
Self-pay price
Some of the lowest prices need a 10- or 12-month plan paid upfront or a membership.
Menopause
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Estradiol
Estradiol · Several generic makers; brands include Estrace, Climara, Vivelle-Dot, Minivelle, Divigel, EstroGel and Evamist
FDA-approved
How you take it
Tablet, skin patch, gel or spray
Moderate to severe hot flashes and night sweats due to menopause
Self-pay price
None of the online providers we compare publishes a price for estradiol tablets, patches, gels or sprays.
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How you take it
Capsule
Preventing endometrial hyperplasia in postmenopausal women with a uterus who take estrogen
Self-pay price
None of the online providers we compare publishes a price for progesterone capsules.
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Vaginal estrogen
Estradiol · Several generic makers; brands include Estrace cream, Vagifem, Yuvafem, Imvexxy and Estring
FDA-approved
How you take it
Vaginal cream, insert (tablet) or ring
Moderate to severe vaginal dryness, irritation and pain with sex from vulvar and vaginal atrophy due to menopause
Self-pay price
None of the online providers we compare publishes a price for vaginal estrogen. Evernow includes vaginal estrogen cream free with a multi-month membership if you qualify, and Wisp lists estradiol vaginal cream from $20 an order.
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How you take it
Tablet
Moderate to severe hot flashes and night sweats (vasomotor symptoms) due to menopause
Self-pay price
None of the online providers we compare publishes a price for Veozah. Astellas’s savings card brings refills to as little as $30 a month for commercially insured patients; it is not valid for cash-paying patients or government plans.
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How you take it
Capsule
Moderate to severe hot flashes and night sweats (vasomotor symptoms) due to menopause
Self-pay price
None of the online providers we compare publishes a price for Lynkuet.
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Low-dose paroxetine
Paroxetine · Brisdelle (7.5 mg capsule); low-dose generic paroxetine tablets from several makers
FDA-approved; used off-label here
How you take it
Capsule (Brisdelle 7.5 mg) or tablet (generic)
Brisdelle 7.5 mg: moderate to severe hot flashes and night sweats associated with menopause
Self-pay price
None of the online providers we compare publishes a price for low-dose paroxetine.
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Compounded bioidentical hormones (BHRT)
Estradiol, estriol, progesterone or testosterone, depending on the formula
Compounded; not FDA-approved
How you take it
Cream, gel or troche prepared by a compounding pharmacy
Self-pay price
None of the online providers we compare publishes a price for compounded estrogen or progesterone creams.
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How you take it
Low-dose cream or gel (compounded, or a product approved for men at a reduced dose); some clinics use injections
Self-pay price
None of the online providers we compare publishes a price for testosterone. Henry Meds adds testosterone for $100 on top of its $149 monthly HRT price, if prescribed.
Skin care
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How you take it
Cream or gel, applied to the skin
Acne vulgaris (tretinoin cream, gel and microsphere gel)
Self-pay price
None of the online providers we compare publishes a monthly price for it.
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How you take it
Tablet, taken by mouth (compounded topical versions also exist)
Heart failure with reduced ejection fraction
Self-pay price
None of the online providers we compare publishes a monthly price for it.
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How you take it
Gel (15%) or cream (20%), applied to the skin
Mild to moderate inflammatory acne (Azelex 20% cream)
Self-pay price
None of the online providers we compare publishes a monthly price for it.
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How you take it
Solution, gel or lotion, applied to the skin
Acne vulgaris
Self-pay price
None of the online providers we compare publishes a monthly price for it.
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How you take it
Tablet or capsule, taken by mouth
Cyclic heavy menstrual bleeding (650 mg tablets)
Self-pay price
None of the online providers we compare publishes a monthly price for it.
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Custom compounded cream
Tretinoin or estriol mixed with actives such as niacinamide, azelaic acid and clindamycin
Compounded; not FDA-approved
How you take it
Cream, mixed by a compounding pharmacy for your prescription
Self-pay price
None of the online providers we compare publishes a monthly price for it.
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Prescription hydroquinone cream
Hydroquinone, usually 4% or more, often with tretinoin, a mild steroid or azelaic acid
Compounded; not FDA-approved
How you take it
Cream, mixed by a compounding pharmacy (Tri-Luma is the approved version)
Self-pay price
None of the online providers we compare publishes a monthly price for it.
Longevity
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Metformin for longevity
Metformin hydrochloride · Generic manufacturers (brand Glucophage is discontinued)
FDA-approved; used off-label here
How you take it
Tablet (immediate or extended release)
Improving blood sugar control in type 2 diabetes, with diet and exercise
Self-pay price
Prices vary by clinic.
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Rapamycin (sirolimus)
Sirolimus · Rapamune (Pfizer) and generic manufacturers; compounding pharmacies
FDA-approved; used off-label here
How you take it
Tablet (generic) or compounded capsule
Preventing organ rejection in kidney transplant patients 13 and older
Self-pay price
Prices vary by clinic.
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How you take it
Subcutaneous injection or nasal spray
Not FDA-approved for any use
Self-pay price
Prices vary by clinic.
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How you take it
Subcutaneous injection; also nasal spray, troche, lozenge or under-the-tongue tablet
Geref injection was approved in 1997 to treat idiopathic growth hormone deficiency in children with growth failure, and in 1990 to test how well the pituitary releases growth hormone
Self-pay price
Prices vary by clinic.
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How you take it
Injection; also nasal spray and rapid-dissolve tablet
Not FDA-approved as a stand-alone drug
Self-pay price
Prices vary by clinic.
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How you take it
Capsule, tablet or troche
Naltrexone 50 mg tablets and Vivitrol injection are approved for alcohol dependence and for blocking the effects of opioids
Self-pay price
Prices vary by clinic.
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How you take it
Oral capsule (compounded)
ProvayBlue and generic methylene blue injections are approved, given IV, for acquired methemoglobinemia
Self-pay price
Prices vary by clinic.
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Vitamin B12 and lipotropic (MIC) injections
Cyanocobalamin or methylcobalamin, often with methionine, inositol and choline
Compounded; not FDA-approved
How you take it
Injection
Cyanocobalamin injection is approved for vitamin B12 deficiency due to malabsorption, such as pernicious anemia
Self-pay price
Prices vary by clinic.
Peptides
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How you take it
Daily injection under the skin (single-dose vial)
Reducing excess abdominal fat in adults with HIV who have lipodystrophy
Self-pay price
None of the providers we track prescribes it, and the maker doesn’t publish a cash price.
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How you take it
Injection under the skin; compounded versions also come as a nasal spray or troche
Brand-name Vyleesi only: acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women
Self-pay price
None of the providers we track publishes a monthly price for compounded PT-141.
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How you take it
Compounded nasal spray, troche or cream
Oxytocin injection only, given in hospital: starting or strengthening labor contractions, and controlling bleeding after delivery
Self-pay price
None of the providers we track publishes a monthly price for compounded oxytocin.
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How you take it
Compounded cream or foam for the skin or scalp
Not FDA-approved for any use
Self-pay price
None of the providers we track publishes a monthly price for topical GHK-Cu.