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Compounded · Not FDA-approved

Enclomiphene: uses, dosing, side effects and where to get it

A daily pill that prompts your body to make more of its own testosterone instead of replacing it, which helps preserve sperm production. It is compounded and not FDA-approved.

White tablets in a small ceramic dish on warm limestone

By the RxLineup editorial team · Fact-checked against provider sites and FDA labels · Updated

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Active ingredient
Enclomiphene citrate
Made by
Compounding pharmacies
Form
Capsule or tablet, compounded
Price online
Some of the lowest prices need a 10- or 12-month plan paid upfront or a membership.

Safety

There is no FDA-approved label, so there are no FDA-reviewed warnings or dosing. Visual disturbances, blood clots and mood changes have been reported with clomiphene, which contains enclomiphene, and long-term safety in men has not been established. Ask for a testosterone blood test before you start and while you take it.

Talk to a licensed clinician about your health history and every medication you take before you start.

Prescription only; compounded and not FDA-approved. Enclomiphene is prepared by a compounding pharmacy for an individual prescription. Compounded products are not FDA-approved, and the FDA does not review them for safety, effectiveness or quality. Enclomiphene citrate is on the FDA’s 503A Category 1 list of bulk substances under evaluation (updated May 14, 2026), so the FDA does not intend to act against licensed pharmacies that compound it for a prescription while it is evaluated. It is not on the final 503A bulks list, and that status can change. It is not a controlled substance.

What enclomiphene is

No enclomiphene product is FDA-approved. Androxal, the enclomiphene studied in phase III trials, was never approved. Enclomiphene is one of the two isomers in clomiphene (Clomid), which is approved for women.

Dosing

Capsule or tablet, compounded, once a day. Online programs list 6.25 mg, 12.5 mg and 25 mg daily capsules. The phase II trial compared those three doses with testosterone gel. Your clinician sets the dose for you.

How well it works

In two phase III trials in overweight men aged 18 to 60 with secondary hypogonadism, 16 weeks of enclomiphene raised testosterone, LH and FSH and kept sperm counts in the normal range, while testosterone gel sharply reduced sperm production. In a phase II trial, 25 mg a day brought morning testosterone to 604 ng/dL after six weeks, vs 500 ng/dL on testosterone gel. Individual results vary.

Enclomiphene cost

Some of the lowest prices need a 10- or 12-month plan paid upfront or a membership. For a full breakdown, read How much does TRT cost online?. For the steps, read How to get TRT online.

Questions, answered

How much does enclomiphene cost online?
Some of the lowest prices need a 10- or 12-month plan paid upfront or a membership.

Is enclomiphene FDA-approved?
No. Enclomiphene is compounded: a compounding pharmacy prepares it for an individual prescription, and it isn’t FDA-approved. Enclomiphene citrate is on the FDA’s 503A Category 1 list of bulk substances under evaluation (updated May 14, 2026), so the FDA does not intend to act against licensed pharmacies that compound it for a prescription while it is evaluated. It is not on the final 503A bulks list, and that status can change. It is not a controlled substance.

How do you take enclomiphene?
Capsule or tablet, compounded, once a day. Online programs list 6.25 mg, 12.5 mg and 25 mg daily capsules. The phase II trial compared those three doses with testosterone gel.

What are the risks of enclomiphene?
There is no FDA-approved label, so there are no FDA-reviewed warnings or dosing. Visual disturbances, blood clots and mood changes have been reported with clomiphene, which contains enclomiphene, and long-term safety in men has not been established. Ask for a testosterone blood test before you start and while you take it.

Can I get enclomiphene online?
A licensed clinician can prescribe enclomiphene after an online or in-person visit.

Sources

  1. FDA: 503A bulk drug substances under evaluation (Category 1 list, updated May 14, 2026)
  2. Kim et al., Oral enclomiphene citrate raises testosterone and preserves sperm counts (two phase III trials), BJU Int 2016
  3. Wiehle et al., Testosterone restoration by enclomiphene citrate (phase II), BJU Int 2013
  4. Clomid (clomiphene citrate) label, Cosette Pharmaceuticals (DailyMed, Feb 2025)