Safety
No boxed warning. The label warns of sleepiness and daytime impairment (don’t drive until you know how it affects you), liver enzyme rises, pregnancy loss and seizures. The most common side effects are headache, tiredness, dizziness and sleepiness.
Talk to a licensed clinician about your health history and every medication you take before you start.
Legal status
Prescription only; FDA-approved. FDA-approved brand-only prescription drug; not a controlled substance and not compounded.
What Lynkuet is
Lynkuet contains elinzanetant, made by Bayer. Approved in 2025. It blocks both neurokinin 1 and neurokinin 3 (NK1 and NK3) receptors. No generic is available.
FDA-approved for moderate to severe hot flashes and night sweats (vasomotor symptoms) due to menopause.
Dosing
Capsule, with or without food. 120 mg (two 60 mg capsules) once a day at bedtime. Rule out pregnancy and check liver tests before starting, and recheck liver tests at 3 months. Your clinician sets the dose for you.
How well it works
In OASIS 1 and 2 (796 women, 12 weeks), women who started with about 13 to 15 moderate to severe hot flashes a day had 8.7 and 9.7 fewer a day on Lynkuet at week 12, compared with 5.4 and 6.5 fewer on placebo. Individual results vary.
Lynkuet cost
None of the online providers we compare publishes a price for Lynkuet. For a full breakdown, read How much does HRT cost without insurance?. For the steps, read How to get HRT online.