Safety
Boxed warning: risk of liver injury (hepatotoxicity), reported after approval. Get liver blood tests before starting and monthly for the first 3 months, then at 6 and 9 months; do not start if liver enzymes or bilirubin are 2 or more times the upper limit of normal. Stop and get care for new tiredness, nausea, vomiting, itching, yellow skin or eyes, pale stools, dark urine or belly pain. Common side effects include abdominal pain, diarrhea, insomnia, back pain and hot flush.
Talk to a licensed clinician about your health history and every medication you take before you start.
Legal status
Prescription only; FDA-approved. FDA-approved brand-only prescription drug; not a controlled substance and not compounded.
What Veozah is
Veozah contains fezolinetant, made by Astellas. Approved in 2023. It is a non-hormonal neurokinin 3 (NK3) receptor blocker. No generic is available.
FDA-approved for moderate to severe hot flashes and night sweats (vasomotor symptoms) due to menopause.
Dosing
Tablet, with or without food. 45 mg once a day. Liver blood tests before starting, monthly for the first 3 months, then at 6 and 9 months. Your clinician sets the dose for you.
How well it works
In two 12-week trials, women who started with about 10 to 12 moderate to severe hot flashes a day had 6.4 and 7.5 fewer a day on Veozah 45 mg at week 12, compared with 3.9 and 5.0 fewer on placebo. Individual results vary.
Veozah cost
None of the online providers we compare publishes a price for Veozah. Astellas’s savings card brings refills to as little as $30 a month for commercially insured patients; it is not valid for cash-paying patients or government plans. For a full breakdown, read How much does HRT cost without insurance?. For the steps, read How to get HRT online.