Safety
No boxed warning. The label warns that blurred vision, spots or flashes can occur, more often at higher doses or with longer use, and may be irreversible; anyone with visual symptoms should stop and have an eye exam promptly. Blood clots and mood changes have also been reported. The label doesn’t cover safety in men.
Talk to a licensed clinician about your health history and every medication you take before you start.
Legal status
Prescription only; FDA-approved. Off-label in men. Not a controlled substance. Generic clomiphene is FDA-approved, so programs usually prescribe the commercial tablet rather than a compounded one.
What clomiphene (Clomid) is
Clomiphene (Clomid) is made by Cosette Pharmaceuticals (Clomid) and generic makers. Clomiphene is FDA-approved only for women. Prescribing it to raise testosterone in men is off-label. It is a mix of two isomers, zuclomiphene and enclomiphene.
FDA-approved for ovulatory dysfunction in women who want to become pregnant.
Dosing
Tablet, on a schedule your prescriber sets (Rex MD lists three times a week). The label dose for women is 50 mg a day for 5 days per cycle. There is no FDA-labeled dose for men.
How well it works
There are no FDA-reviewed trials in men. In a small study of 12 healthy men aged 25 to 38 taking 50 mg a day for 30 days, testosterone rose 146% on average, with LH up 177% and FSH up 170%. Individual results vary.
Clomiphene (Clomid) cost
Membership fees, where they apply, are added in; Rex MD includes Clomid in its program price without a separate figure. For a full breakdown, read How much does TRT cost online?. For the steps, read How to get TRT online.