Safety
No boxed warning on the current Prometrium label. Its warnings cover blood clots, stroke and heart attack, breast cancer and vision problems, drawn from the Women’s Health Initiative estrogen-plus-progestin trial. Do not use it with a history of breast cancer, blood clots, stroke or heart attack, liver disease or unexplained vaginal bleeding. The capsules contain peanut oil, so they are not for people with a peanut allergy.
Talk to a licensed clinician about your health history and every medication you take before you start.
Legal status
Prescription only; FDA-approved. FDA-approved and sold as a generic; not a controlled substance. Pharmacies may also compound progesterone creams or troches for an individual prescription, and those are not FDA-approved.
What progesterone (micronized) is
The current Prometrium label (revised 02/2026) has no boxed warning.
FDA-approved for
- Preventing endometrial hyperplasia in postmenopausal women with a uterus who take estrogen
- Secondary amenorrhea (absent periods)
Dosing
Capsule, once a day at bedtime. 200 mg at bedtime for 12 days of each 28-day cycle with daily estrogen. For secondary amenorrhea, 400 mg at bedtime for 10 days. Your clinician sets the dose for you.
How well it works
In a 3-year trial of 358 postmenopausal women with a uterus, endometrial hyperplasia occurred in 6% of women taking Prometrium 200 mg (12 days a cycle) with conjugated estrogens, compared with 64% on estrogen alone. Individual results vary.
Progesterone (micronized) cost
None of the online providers we compare publishes a price for progesterone capsules. For a full breakdown, read How much does HRT cost without insurance?. For the steps, read How to get HRT online.