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System Labs weight loss review

System Labs (System Laboratories, Inc., San Francisco) sells compounded tirzepatide, which its page calls compounded GLP-1/GIP, at $179 a month for every dose after a $99 first month. The price covers injection supplies, clinician support by chat and free 2-day shipping, with no per-visit fees, and The Pharmacy Hub in Miami compounds its medications.

By the RxLineup editorial team · Fact-checked against provider sites and FDA labels · Updated

· How we rate

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We don’t cover every program on the market. Prices change often, so confirm the details with the provider before you enroll.

Full disclosure
System Labs logo

Rated 8.4 out of 10, Very good

How we score

From $179/mo Compounded GLP-1/GIP (tirzepatide), monthly supply at every dose, after a $99 first month, with injection supplies, clinician support and free 2-day shipping included

Only providers that pay us appear in our rankings and reviews, and we’re paid when you sign up through our links. How we make money

Check eligibility with System Labs (opens in a new tab)

on systemlabs.com

Medications
Tirz
Insurance
Self-pay
Same price at every dose
Yes

What we like and what to watch

Strengths

  • Same $179 monthly price at every dose
  • One price covers medication, supplies, clinician support and shipping
  • Names its compounding pharmacy and medical advisors
  • LegitScript certified; offered in all 50 states, by treatment
  • Free 2-day shipping; pause or cancel anytime

Drawbacks

  • Its page calls the drug “compounded GLP-1/GIP” and doesn’t name tirzepatide on screen
  • Compounded medication only; no Wegovy or Zepbound
  • The $99 headline price is for the first month only
  • No refunds once the pharmacy ships; cancel by emailing support
  • No video visit described; care is by chat

Best for

One flat monthly price for compounded tirzepatide at every dose.

How System Labs scores

Scored out of 10 on our five weighted criteria. The overall score, 8.4, is their weighted average. How we rate

  • Price & value 30%

  • Clinical care 25%

  • Medication options 20%

  • Transparency 15%

  • Experience 10%

What it costs

System Labs pricing, checked Nov 3, 2026
Item Price
Starting price Compounded GLP-1/GIP (tirzepatide), monthly supply at every dose, after a $99 first month, with injection supplies, clinician support and free 2-day shipping included $179/mo
Compounded semaglutide Not offered
Compounded tirzepatide $179/mo
Membership No membership. The monthly price covers the medication at every dose, injection supplies, ongoing clinician support and free 2-day shipping, with no per-visit fees None
Insurance Cash pay; System Labs doesn’t take insurance Self-pay

Want a full estimate with membership and dose changes? Try the GLP-1 cost calculator.

Medications offered

Small unlabeled glass vial on a warm limestone surface

Compounded medications are prepared by licensed pharmacies and are not FDA-approved.

Safety

One of these treatments carries an FDA boxed warning, the strongest warning on a label: tirzepatide.

TirzepatideNot FDA-approved
GLP-1 medications carry a boxed warning for thyroid C-cell tumors and are not for people with a personal or family history of medullary thyroid carcinoma or MEN 2. FDA label

Not medical advice. A licensed clinician decides whether a treatment is right for you; read the full prescribing information before you start.

What’s included

  • A licensed clinician reviews a 2-minute intake and follows up by chat
  • Clinician-guided dose increases and ongoing care-team support
  • Injection supplies included
  • Free 2-day temperature-controlled shipping; pause or cancel anytime

How it works

Four steps, from the first questionnaire to ongoing dose changes.

Plain shipping box on a sunny front step

  1. Answer an online health questionnaire

    Your history, current medications and goals. It usually takes a few minutes.

  2. A licensed clinician reviews it

    If System Labs needs more information, they’ll message you or book a visit.

  3. Medication ships to your door

    If you are prescribed, a licensed pharmacy ships your medication and supplies.

  4. Ongoing check-ins and dose changes

    Your clinician adjusts your dose over time and helps with side effects.

Is System Labs legit?

What System Labs’s own pages show, checked on Nov 3, 2026. LegitScript and a named pharmacy are checks on who prescribes and who fills; neither rates the care.

Who prescribes
A 2-minute online intake reviewed by a U.S.-licensed physician, nurse practitioner or physician assistant, who reaches out by chat; its FAQ says a telemedicine consultation is offered after review, follow-ups and monitoring are built into the care model, patients can contact their clinician at any time, and the provider orders baseline labs when a therapy needs them. The Pharmacy Hub (Miami, Florida) compounds its medications. Its medical advisors are Dr. Marc Gruner (sports medicine), Dr. Jonathan Hinds (board-certified in emergency medicine) and Dr. Gregory Tennant (orthopedic trauma surgeon).
LegitScript
Displays LegitScript certification, a third-party check against licensing and pharmacy rules. It isn’t a rating of the care.
Pharmacy
Names its pharmacies: The Pharmacy Hub.
Prices
Publishes a price before you sign up.
Refunds and terms
No refunds once the pharmacy ships; cancel by emailing support.
Last checked
November 3, 2026, against 4 of its own pages.

The fine print

Prices
As listed on systemlabs.com when we checked on Nov 3, 2026. Prices change often and some are introductory, so confirm the total before you pay.
Refunds and guarantee
No refunds once the pharmacy ships; cancel by emailing support
Availability
All 50 states; availability of each treatment depends on state telehealth rules and pharmacy licensing
LegitScript certified
Yes

Alternatives

Other highly rated programs, highest score first, and how each compares head to head.

  1. 01
    Eden

    A flat all-in price with a results warranty

    Rated 9.1 out of 10, Excellent

    From $99/mo

    Visit site for Eden (opens in a new tab)
  2. 02
    Measured

    Low compounded prices, plus prior authorization help for brand-name GLP-1s

    Rated 9.0 out of 10, Excellent

    From $199/mo

    Visit site for Measured (opens in a new tab)
  3. 03
    MEDGm

    Labs and video access included, with tablets and brand-name options

    Rated 9.0 out of 10, Excellent

    From $299/mo

    Visit site for MEDGm (opens in a new tab)
  4. 04
    Gala GLP-1

    Coaching and app support at a low flat price

    Rated 8.8 out of 10, Excellent

    From $129/mo

    Visit site for Gala GLP-1 (opens in a new tab)

Guides to read before you choose

More on weight loss

Questions, answered

Is System Labs legit?
System Labs is run by System Laboratories, Inc. of San Francisco and shows LegitScript’s seal for systemlabs.com. U.S.-licensed physicians, nurse practitioners and physician assistants review each intake and decide whether to prescribe, and not every consultation ends in a prescription. Its compounding pharmacy partner is The Pharmacy Hub in Miami. Its GLP-1/GIP is compounded: it is not Zepbound or Mounjaro and not a generic of them, and it isn’t FDA-approved.

How much does System Labs GLP-1 cost?
As of November 2026, its compounded GLP-1/GIP (tirzepatide) is $99 for the first month, then $179 a month at every dose, with injection supplies, clinician support and free 2-day shipping included and no per-visit fees. Refills are automatic, and you can pause or cancel at any time.

What is System Labs compounded GLP-1/GIP?
A compounded injection that acts on both the GLP-1 and GIP hormone receptors. Tirzepatide is the only approved medicine that does both, and the page’s product data (not shown on screen) names it “Tirzepatide & B3”, but the page itself doesn’t use the word tirzepatide, so ask your clinician to confirm the drug and dose. Compounded tirzepatide is not Zepbound or Mounjaro and isn’t FDA-approved.

Does System Labs take insurance?
No. System Labs is cash pay and doesn’t bill insurance. For weight loss, System Labs’s published price is from $179/mo.

What GLP-1 medications does System Labs prescribe?
System Labs offers Tirzepatide (compounded). A licensed clinician decides whether a medication is appropriate for you. Compounded medications are not FDA-approved.

Can I cancel System Labs?
No refunds once the pharmacy ships; cancel by emailing support

Is System Labs available in my state?
System Labs serves: All 50 states; availability of each treatment depends on state telehealth rules and pharmacy licensing. Check that System Labs serves your state for weight loss treatment at the start of the intake.

Sources (checked Nov 3, 2026)

  1. System Labs: GLP-1 page
  2. System Labs: homepage
  3. System Labs: FAQ
  4. System Labs: Terms

System Labs

8.4/10 ·  From $179/mo

Check eligibility with System Labs (opens in a new tab)