How to get a rapamycin prescription online

Rapamycin (sirolimus) is an FDA-approved drug, so a licensed clinician can prescribe it off-label for longevity, and a few online clinics specialize in doing exactly that. In our comparison, two do: AgelessRx and Healthspan. Both charge $65 a month as of October 2026, both build lab work into the price, and both prescribe a low dose once a week rather than the daily transplant dose.

Here is how the process works, step by step, and how the two clinics differ.

Before you start: what you’re signing up for

Rapamycin extends lifespan in mice, but no human trial has shown it extends life or slows aging. The largest human study, the 48-week PEARL trial, found low weekly doses relatively safe without changing its main outcome, visceral fat. Women taking 10 mg gained lean mass and reported less pain. The drug’s label carries a boxed warning: immunosuppression may increase susceptibility to infection and the possible development of lymphoma. We cover the evidence in detail in rapamycin for longevity.

Step 1: Choose a clinic

Pick AgelessRx if you want rapamycin alongside other treatments from one clinic. Pick Healthspan if you want FDA-approved generic tablets as the default. Our longevity clinic rankings score both against nine other clinics.

Step 2: Complete the online intake

Both clinics start with an online health questionnaire, with no in-person visit. Expect questions about:

• Your age and goals. AgelessRx currently evaluates adults aged 40 and older who are clinically stable, and says age alone doesn’t decide eligibility.
• Your medical history, including infections, cancer, surgery plans, kidney and liver health, and pregnancy plans.
• Every medicine and supplement you take. Strong CYP3A4 inhibitors and inducers, including some antibiotics and antifungals, change sirolimus blood levels, and grapefruit juice does too.
• Your immune function and vaccinations. The label says to avoid live vaccines while on the drug.

Be complete. These answers decide whether rapamycin is appropriate for you and at what dose.

Step 3: Get your labs

Lab work is where these programs differ most from a quick online prescription. At AgelessRx, once you’re approved, your care team asks you to complete blood work at a local lab before your treatment is prepared and shipped, and ongoing labs are part of the plan. Healthspan “strongly recommends” its included panel, which covers a complete metabolic profile, a complete blood count, a lipid panel, HbA1c and high-sensitivity C-reactive protein. It also offers a sirolimus blood level test to check how much of the drug you absorb.

Those tests line up with the label’s warnings: sirolimus can raise cholesterol and triglycerides, affect kidney function and increase infection risk.

Step 4: The clinician decides, and sets a dose

If a clinician approves treatment, you get a weekly dosing schedule. Healthspan says it typically starts at 3 mg a week and raises the dose over time, usually to 5 to 8 mg a week. AgelessRx gives each patient a titration schedule based on labs, response and its own trial data.

The form changes the dose. PEARL used 5 mg or 10 mg of compounded rapamycin a week, which its preprint equates to about 1.43 mg or 2.86 mg of generic rapamycin. AgelessRx reports that its compounded rapamycin is roughly a third as bioavailable per milligram as commercial tablets, based on blood levels in 44 commercial and 23 compounded users, and Healthspan prescribes generic first for the same reason. Ask which form you’re getting, and don’t switch forms without a new dose.

Step 5: Delivery, follow-up and adjustments

Both clinics ship for free. AgelessRx bills and ships monthly and offers unlimited provider messaging and dose adjustments. Healthspan’s care team reviews your labs regularly and adjusts the protocol. Both say you can pause, modify or cancel.

Know the side effects to report. AgelessRx lists mouth sores, nausea, diarrhea, headache, changes in cholesterol, more infections and slower wound healing as possible side effects; in PEARL, it says, mild stomach symptoms and mouth sores affected roughly 1 in 5 participants. Tell your clinician before any planned surgery, since sirolimus can slow wound healing.

What it costs over a year

At $65 a month, a year of rapamycin with lab monitoring costs $780 at either clinic, as of October 2026. Neither clinic adds a membership fee. If you add other treatments at AgelessRx, each has its own price; metformin, for example, starts at $25 a month. Healthspan’s other protocols start at $30 a month (metformin) and $40 (low-dose naltrexone). Prices for every treatment are on our rapamycin page and the longevity hub.

If you’re turned down, or decide to stop

A clinician may decline to prescribe if your labs, your other medicines or your history make rapamycin a poor fit. That’s the screening working as intended, and it is worth taking seriously rather than shopping for a clinic with a lighter intake. AgelessRx says it considers health history, medications, immune function and lab results alongside age, and Healthspan says medication is “strictly contingent upon a comprehensive medical review and initial screening process.”

If you stop, tell the clinic before your next billing date. Both clinics bill monthly, and compounded medication generally can’t be returned once a pharmacy has dispensed it.

Keep your regular doctor in the loop

Even when an online clinic prescribes rapamycin, your regular doctor and any other clinician who treats you need to know. Sirolimus slows wound healing, its blood levels change with many common drugs that act on CYP3A4, and you should avoid live vaccines while taking it, all of which matter when someone else prescribes or operates. Bring your latest lab results to your next routine visit, and list rapamycin on any medicine form you fill in.

Questions to ask before you pay

• Is the rapamycin generic or compounded, and what is the dose in that form?
• Which labs are included, and how often are they repeated?
• Who reviews my results, and how quickly do they respond to messages?
• What happens if a lab result comes back abnormal?
• Which pharmacy fills the prescription? Neither clinic names its pharmacies on the pages we read.
• How do I pause or cancel, and is anything refundable once it ships?

The bottom line

Getting rapamycin online is straightforward: an intake, a lab panel, a clinician’s decision and a weekly prescription shipped to your door, for $65 a month at AgelessRx or Healthspan as of October 2026. The care that matters is the monitoring, because sirolimus is an immunosuppressant with a boxed warning and its longevity benefit in people is unproven. Choose the program whose lab schedule and form of rapamycin you understand, and keep your regular doctor informed.